Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF and IL18 but not CXCL12
نویسندگان
چکیده
منابع مشابه
Clinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12.
BACKGROUND Tumour necrosis alpha (TNF alpha) blocking agents lead to pronounced clinical effects and reduced synovial infiltrate in rheumatoid arthritis. Laboratory and clinical studies suggest that TNF alpha independent pathways play a role in the disease. OBJECTIVES To evaluate the immunopathological effects of combination therapy on rheumatoid synovial tissue in order to identify TNF alpha...
متن کاملCombination DMARD therapy for rheumatoid arthritis.
approaches needs to be considered; triple therapy has been reported to be well tolerated at three to five years, while similar data are not available for methotrexate and cyclosporin A. The success of combination DMARD therapy in recent double blind controlled studies is encouraging.2223 As is frequently the case, however, the success of these approaches raises as many questions as it answers. ...
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OBJECTIVES To compare the clinical and radiological efficacy of initial vs delayed treatment with methotrexate (MTX) and infliximab (IFX) in patients with recent onset rheumatoid arthritis (RA). METHODS In a post hoc analysis of the BeSt study (for Behandel Stratagieen, Dutch for treatment strategies), 117 patients who started initial MTX+IFX were compared with 67 patients who started MTX+IFX...
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15 صفحه اولEffectiveness of sulfasalazine and methotrexate in 1102 DMARD-naive patients with early RA.
OBJECTIVE To compare baseline characteristics, responses and drug survival in patients with early RA starting SSZ or MTX in a real-life setting. METHODS The analyses included DMARD-naïve patients with RA (disease duration ≤ 1 year) starting SSZ or MTX. Three- and 6-month effectiveness was compared by unadjusted analysis and with adjustment for propensity score quintile. In addition, effective...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2005
ISSN: 0003-4967
DOI: 10.1136/ard.2004.024927